The fifth film in the horror survival gaming series is expected to arrive in cinemas in 2012.
Anderson told Collider: "There's a great action sequence which we've been inspired by from the fifth game, which is where the characters are driving in a Hummer through the desert and they're being chased by zombies shooting machine guns on motorbikes.
"We've taken that and we've kind of run with it. We're not gonna use a Hummer this time - we're gonna use a Rolls Royce Phantom, cause no-one's ever done a car chase with a Rolls Royce Phantom before. And I've discovered why, because it's really, really expensive."
He added: "We're bringing in the Las Plagas parasite, which I love because it allows the undead to basically run around, ride motorbikes and shoot machine guns, which no-one's done before."
He said: "[The new characters] is something that's kind of come out of Milla and I talking to fans, feeling the characters that people wanted to come in.
"[We chose] three of those that seem to be the fan-favourites that we'd never touched on - Leon Kennedy, Ada Wong and Barry Burton."
Anderson is also currently attached to the historical drama Pompei, which follows the aftermath of the volcanic natural disaster.
He has also completed The Three Musketeers, which co-stars his wife Jovovich and Christoph Waltz.
Watch the trailer for The Three Musketeers below: