The BBFC granted the controversial horror an 18 certificate after previously branding the movie "unacceptable" for audiences, highlighting the protagonist's "total degradation, humiliation, mutilation, torture, and murder of his naked victims".
Two minutes and 37 seconds were cut from Tom Six's film in order to obtain an 18.
Ian Sadler, sales director of UK distributor Eureka Entertainment, said: "We are really pleased that after nearly four months of detailed discussion and debate, we have been able to reach an agreement with the BBFC and to produce a very viable cut of the film which will both excite and challenge its fans.
"Naturally we have a slight disappointment that we have had to make cuts, but we feel that the storyline has not been compromised and the level of horror has been sustained."
Six previously blasted the BBFC's decision to reject his film, saying: "Apparently I made a horrific horror film, but shouldn't a good horror film be horrific? My dear people it is a f**king MOVIE. It is all fictional. Not real. It is all make-belief. It is art."
Details of The Human Centipede II's theatrical and DVD release are expected to be announced next week.
> The Human Centipede 2 (Full Sequence) - new poster
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Watch a trailer for The Human Centipede II (Full Sequence) below: