Six's controversial movie is to premiere at this year's FrightFest, after it was finally passed by the British Board of Film Classification (BBFC) following two minutes and 37 minutes of cuts.
He told Moviefone: "I hate animal cruelty so I would never do anything with that in any of my films, but in my opinion it's film, it's make-believe, it's art. It's actors coming in, and we have lots of fun on the set. How can it go too far, then?"
Six added that he thinks getting a strong reaction from the audience is the core of filmmaking.
"If you make a great comedy and you're laughing your ass of and you're really hurt from the laughing - I love that," he said.
"If a film in any way does that with you, that you're really f**ked up or you have a strong emotion, then it works I think. Because it's terrible if you see a film and you don't care."
On the cuts made to the movie, Six said: "People have the choice; there's a version with some extreme things taken out, and I think it's only a few minutes they had to take out.
"People can see almost all of it. But maybe it's a good thing that some people are missing [said scenes]."
The BBFC delivered the original ruling in June because it claimed that the film made an explicit link between sexual arousal and violence.
> Poll: Was the BBFC right to ban 'The Human Centipede 2'?
Watch the trailer for The Human Centipede II (Full Sequence) below: