Six's controversial movie is to premiere at this year's FrightFest, after it was finally passed by the British Board of Film Classification (BBFC) following two minutes and 37 minutes of cuts.
© Rex Features
He told Moviefone: "I hate animal cruelty so I would never do anything with that in any of my films, but in my opinion it's film, it's make-believe, it's art. It's actors coming in, and we have lots of fun on the set. How can it go too far, then?"
Six added that he thinks getting a strong reaction from the audience is the core of filmmaking.
"If you make a great comedy and you're laughing your ass of and you're really hurt from the laughing - I love that," he said.
"If a film in any way does that with you, that you're really f**ked up or you have a strong emotion, then it works I think. Because it's terrible if you see a film and you don't care."
On the cuts made to the movie, Six said: "People have the choice; there's a version with some extreme things taken out, and I think it's only a few minutes they had to take out.
"People can see almost all of it. But maybe it's a good thing that some people are missing [said scenes]."
The BBFC delivered the original ruling in June because it claimed that the film made an explicit link between sexual arousal and violence.
> Poll: Was the BBFC right to ban 'The Human Centipede 2'?
Watch the trailer for The Human Centipede II (Full Sequence) below:
