Solipsist Films has acquired the rights to the forthcoming graphic novel from Top Cow Productions, according to The Hollywood Reporter.
George Mahaffey and Christian Duce's story is set in the 1930s, when the American Midwest was plagued with 'black blizzards' - huge dust storms that blotted out the sun.
In the Dust stars a special agent who discovers that mysterious disappearances are the work of vampires using the dust cloud as cover to move about during the day. He is forced to team up with the remnants of Al Capone's gang to protect Chicago from an invasion of the undead.
Mahaffey will write the adaptation, which is being executive produced by comics veteran Marc Silvestri. Solipsist Films' Stephen L'Heureux and Top Cow's Matt Hawkins will produce In the Dust.
L'Heureux recently worked on vampire thriller Undying Love - another comic book adaptation - and is producing Robert Rodriguez and Frank Miller's Sin City sequel A Dame to Kill For.
The In the Dust graphic novel is due out in 2012.