According to Deadline, the Gone, Baby, Gone director is the studio's first choice to helm the apocalyptic thriller.
Adapted from the 1978 novel by King, The Stand will follow the aftermath of an apocalypse brought on by a biological weapon and the ensuing struggle between the world's few survivors.
The actor and director is currently working on Argo, which stars Bryan Cranston, John Goodman and Alan Arkin.
Affleck will release Argo on September 14, 2012.
> Ben Affleck casts Tayor Schilling in Argo
Watch the trailer for Ben Affleck's The Town below: