The Rum Diary star revealed that he is angered by accusations of being a sell-out, claiming that he never realised the film would become so popular.
"I wouldn't change anything, no. Because I think I went into it innocently, and it became what it became," Depp told The Guardian. "And now they want to tear me down. Instantly, as soon as I did Pirates II, they say, 'Oh, he's selling out'."
He continued: "What the f**k does that mean, selling out? What if I did Ed Wood II, is that selling out? I mean, it's not like I was ever looking to become franchise boy, I was never looking to become anything like that. I just latched on to a character I loved."
Last week, Depp revealed that he thought he was going to die during a recent plane flight to Los Angeles.
The actor, who recently finished shooting Dark Shadows, has criticised the modern portrayal of vampires in cinema, promising a return to their classic image in his upcoming film.
Dark Shadows is scheduled for release in cinemas on May 11, 2012.
Watch the trailer for The Rum Diary below: