The Oscar-tipped drama sees Clooney team up with Sideways director Alexander Payne to play a Hawaiian land baron who is forced to take care of his daughters after his wife is put into a coma following a boating accident.
Shailene Woodley, Judy Greer, Beau Bridges, Robert Forster and Matthew Lillard co-star in The Descendants, which opens in UK cinemas on January 27.
The film is based on the novel of the same name by Kaui Hart Hemmings, and is Payne's first big screen outing since 2004's Sideways. The director's credits also include About Schmidt and Election.
The Descendants is released on January 27, 2012 in the UK.
View our Descendants picture gallery below: