The director revealed that he hired Pattinson for the film despite his Twilight stigma as he knew intuitively that the young star was right for the role.
"You start with the basics. How old is he? What does he look like? Is the character very nerdy? Is he handsome and devilish?" Cronenberg explained to MTV News of the casting process.
"Is he an intellectual? You think about all these things and you think about the actors who could possibly project the things that you need from this character. Ultimately, I felt he was the guy. Once again, intuition."
Cronenberg added that while Cosmopolis is a far cry from Pattinson's Twilight past, he believes that the part offered a challenge which he passed with flying colours.
"This is an unusual jump for him. He said it himself. It's scary. It's a scary thing because he's never really had to carry a movie quite that way before, totally on his own. He's in every scene. He's almost in every shot, so scary for him, but for an actor, scary is good. You don't want to be bored. You don't want to be too confident," Cronenberg said.
"Really, he's fantastic. He's sensational. Really, I'm telling you. He's a great actor. It's obvious in the movie. It's not like maybe yes, maybe no. It's obvious."
Cosmopolis, which also stars Jay Baruchel, will open in 2012.
Watch Robert Pattinson in The Twilight Saga: Breaking Dawn - Part 1's trailer below: