The video shows Chris Hemsworth and a group of 20-something friends who get more than they bargain for when they plan a holiday in a remote house in the wild.
Whedon (The Avenger) and Goddard (Cloverfield) wrote the script together. Whedon is producing the film with Goddard as director.
Cabin in the Woods also features Richard Jenkins, Bradley Whitford, Kristen Connolly, Brian J White, Amy Acker, Fran Kranz and Jesse Williams.
The long-delayed film was formerly scheduled for a 2010 release.
The Cabin in the Woods will open in cinemas on April 13.