The comedian has played record exec Ian Hawke in all three Chipmunks movies and previously defended his work on the franchise when some fans accused him of 'selling out'.
In an interview with Indie Wire, Cross admitted that shooting the final Chipmunks film was incredibly frustrating.
"This last film was literally, without question, the most unpleasant experience I've ever had in my professional life," Cross told the website. "It's safe to say I won't be working with some of those people ever again. Not the actors. And the director [Mike Mitchell] was great. We got along."
The Arrested Development star added: "There were a couple of people, though… it was just a really awful, unpleasant experience."
Cross went on to reveal that the upside of appearing on the big screen alongside the Chipmunks is that he's been recognised in remote parts of the world including China, Zimbabwe and "a teeny tiny town in Mozambique".
Alvin and the Chipmunks: Chipwrecked, which also stars Jason Lee, is now playing in US cinemas and UK cinemas.
Cross's television series The Increasingly Poor Decisions of Todd Margaret returns for a second season to IFC in 2012.
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Watch a trailer for Alvin and the Chipmunks: Chipwrecked below: