The Girl with the Dragon Tattoo director - who was previously in the running for a Spider-Man film - has revealed how he envisioned the opening to the Marvel Comics' franchise.
"My impression [of] what Spider-Man could be is very different from what [Sam Raimi] did or what Sam wanted to do," Fincher told io9.
"I think the reason he directed that movie was because he wanted to do the Marvel Comics superhero. I was never interested in the genesis story. I couldn't get past a guy getting bit by a red and blue spider. It was just a problem. It was not something that I felt I could do straight-faced.
"I wanted to start with Gwen Stacy and the Green Goblin, and I wanted to kill Gwen Stacy."
"The title sequence of the movie that I was going to do was going to be a ten minute - basically a music video, an opera, which was going to be the one shot that took you through the entire Peter Parker [backstory]," he said.
"Bit by a radioactive spider, the death of Uncle Ben, the loss of Mary Jane, and [then the movie] was going to begin with Peter meeting Gwen Stacy. It was a very different thing, it wasn't the teenager story. It was much more of the guy who's settled into being a freak."
The rebooted Spider-Man franchise is being directed by Marc Webb, with Andrew Garfield in the starring role.
Fincher recently discussed his comic book movie projects The Goon and Black Hole.
Webb's The Amazing Spider-Man will debut on July 3, 2012.
Watch a teaser trailer for The Amazing Spider-Man below: