The Red Skull will apparently appear alongside Loki in Joss Whedon's movie.
"Charging straight out of theaters and on to your tabletop, Marvel's the Avengers Movie HeroClix set features heroes like Captain America and Thor as they battle the villainy of the Red Skull and Loki," said the product announcement.
It was already known that Tom Hiddleston would reprise his Thor role as Loki in the film.
The Red Skull was portrayed by Hugo Weaving in the 2011 Captain America: The First Avenger movie, but it is unknown whether he will return to the role for the ensemble superhero film.
It has also been rumoured that the alien Skrull race will appear as villains in the movie.
The Avengers will debut on May 4.
Watch the Avengers trailer below: