The director said that McCarthy, who has already been nominated for a Screen Actors Guild award for her role as Megan in the 2011 comedy, is his pick to take home the Oscar next month, though she is not the film's only chance at victory.
"I'm really pulling for Melissa [McCarthy]. I think we got a good shot with Melissa [for 'Best Supporting Actress']. I think the girls have a good shot for the screenplay," Feig explained to MTV News.
In addition to his faith in Kristen Wiig and Annie Mumolo's screenplay, Feig said that he would not rule out a 'Best Picture' nod, though he is not getting his hopes up for the prize.
"Look, nothing would make me happier. I think that's a real tough one because the way the voting for the Academy is set up for 'Best Pictures' this year is tough," he explained.
"We have to get a lot of, like, 'best movie of the year' votes, which, like, we're good, but we're not the best movie of the year. I'd like to say we were, but what an ass I would sound like if I did say that."
Feig recently revealed that he would consider going ahead with Bridesmaids 2 despite reports that Kristen Wiig had declined to be involved.
However, McCarthy insisted that she would not reprise her role as Megan unless Wiig consented to join the project.
Watch the trailer for Bridesmaids below: