The Weeds star will take over the role of Gloria Steinem following Demi Moore's exit from the porn biopic, reports US Weekly.
Moore dropped out of the project last week following her hospitalisation on Monday (January 23).
She had originally been added to the cast earlier this month alongside Eric Roberts and former OC star Adam Brody.
Lovelace stars Amanda Seyfried, with an ensemble cast including James Franco, Juno Temple, Sharon Stone, Hank Azaria and Peter Sarsgaard.
It is currently in production and is scheduled for release later this year.
> Demi Moore released from hospital