Apatow will receive the Herb Sargent Award for Comedy Excellence in recognition of his career achievements at the WGA East's February 19 gala.
His film Bridesmaids has been nominated in the 'Original Film' category against 50/50, Midnight in Paris, Win Win and Young Adult.
Ryan's Hope creator Claire Labin will also be honoured at the Writers Guild of America's East Coast Awards when she receives the Ian McLellan Hunter Award.
The Writers Guild of America's East Coast Awards will be hosted by former Saturday Night Live star Rachel Dratch at BB King Blues Club in New York City.
The WGA's West Coast Awards will be held simultaneously in Los Angeles from the Hollywood Palladium with hosts New Girl star Zooey Deschanel and Community's Joel McHale.
McHale previously joked about co-hosting with Deschanel, saying: "I'm deeply excited to co-host the WGA Awards with Zooey Deschanel. She has that rare combination in that she's beautiful, funny, and smells good."
The WGA recognises excellence in film, television, news media, gaming, radio and promotional writing and graphic animations.
> Bridesmaids cast to present at Oscars 2012
> Chris O'Dowd: 'I don't want a Bridesmaids sequel'
Watch a Bridesmaids trailer below: