According to Deadline, the fourth Mission: Impossible film will today earn a global gross of $603 million, beating Cruise's previous highest-grosser - 2005's War of the Worlds.
War of the Worlds had a global gross of $591.7 million.
In Ghost Protocol, Cruise reprises his spy role as Ethan Hunt, whose team is blame for an attack in Russia and must try to clear their organisation's name after being shut down.
Cruise, who will turn 50 this year, previously said that he will continue to make action films.
"I'm just going to keep going, as long as I can do it. I love making action movies," he said.
Watch the trailer of Mission: Impossible - Ghost Protocol below: