The found footage superhero movie, which centres on three teens gifted with extraordinary powers, pulls in more than £2 million at UK cinemas to emerge as the number one movie ahead of Dwayne Johnson's Journey 2: The Mysterious Island.
George Clooney's The Descendants drops a spot to number three, while War Horse's three-week reign at the chart summit comes to an end as it slips down to number four.
Elsewhere, the top ten also saw debuts from Man on a Ledge, a heist thriller starring Sam Worthington, and Roman Polanski's all-star ensemble Carnage.
The UK box office top ten in full:
1. (-) Chronicle - £2,193,072
2. (-) Journey 2: The Mysterious Island - £1,200,587
3. (2) The Descendants - £1,112,964
4. (1) War Horse - £889,687
5. (-) Jack and Jill - £848,814
6. (-) Man on a Ledge - £697,394
7. (3) The Grey - £521,188
8. (4) A Monster in Paris - £474,941
9. (5) The Artist - £377,889
10. (-) Carnage - £298,733
Watch the trailer for Chronicle below: