The Vow centres on Leo, a man who must win back the love of his wife Paige (Rachel McAdams), after an accident erases her memory.
Tatum said that while very few have dealt with such a tragic accident, he believes everyone can relate to the pain of a difficult relationship.
"It's told through the guy's perspective," Tatum explained to MTV News.
"You don't just need some horrible accident to not really know someone in a relationship, you can kind of grow apart and they can not recognise them and to see somebody try so hard to get back to that is cool."
McAdams recently revealed that she was concerned about her romantic chemistry with Tatum in The Vow as they have a sibling relationship in real life.
The Vow opens in cinemas on February 10.
Watch Channing Tatum and Rachel McAdams talk sweets and sweaters with Digital Spy below: