Produced by Leonardo DiCaprio, Harker is a reimagining of Bram Stoker's famous Dracula novel, reports New York Magazine.
In the novel, Jonathan Harker is a lawyer who travels to Transylvania to act as an estate agent for Count Dracula, who wants to move to England.
However, in the upcoming horror tale Harker is a Scotland Yard detective investigating murders committed by Dracula in England.
Under Warner Bros, Harker is written by Lee Shipman and Brian McGreevy and will be directed by Jaume Collet-Serra.
Crowe has previously been rumoured to star in the RoboCop remake and Darren Aronofsky's biblical epic Noah.
Earlier this week, David Hasselhoff jokingly approached the Gladiator actor to star with him in a movie remake of Knight Rider.
Watch the trailer for Russell Crowe's Robin Hood below: