The black and white homage to silent cinema, which centres on a Hollywood actor struggling to make the transition to talkies, took home BAFTAs for 'Best Film', 'Director' and 'Original Screenplay' for Michel Hazanavicius and a 'Best Actor' gong for its star Jean Dujardin.
The Artist also secured wins in technical categories for 'Cinematography', 'Music' and 'Costume Design'.
Watch the trailer for The Artist below:
Meryl Streep followed up on her Golden Globes victory by taking home the 'Best Actress' prize for her role as Margaret Thatcher in The Iron Lady. The supporting gongs went to Christopher Plummer for Beginners and The Help's Octavia Spencer.
British spy thriller Tinker Tailor Soldier Spy won 'Outstanding British Film' and 'Adapted Screenplay'. Senna scooped BAFTAs for 'Best Documentary' and 'Editing'.
Paddy Considine won 'Outstanding Debut by a British Writer, Director or Producer' for his brutal first feature Tyrannosaur.
The 'Orange Rising Star Award', the only BAFTA to be voted for by the public, went to Anuvahood star Adam Deacon.
Elsewhere, John Hurt received 'Outstanding British Contribution to Cinema' and Hugo director Martin Scorsese accepted the 'Academy Fellowship'.
Scorsese said upon receiving the BAFTA from Max von Sydow: "This award has particular resonance, because it is the first award I've ever shared with Michael Powell and Emeric Pressburger, the knights templar of British cinema."
> Orange BAFTA Film Awards 2012 winners list
> BAFTAs 2012: Red carpet arrivals gallery
> BAFTAs 2012: Winners gallery
View pictures of the major winners from the BAFTAs below: