The pair join Justin Long, Peter Dinklage and Evan Rachel Wood in the Kat Coiro-helmed indie comedy, reports Variety.
A Case of You is based on an original screenplay co-written by Long, his brother Christian and Keir O'Donnell. The latter will star in a supporting role, along with Busy Phillips.
The story focuses on a writer who wins the affections of a woman by using an embellished profile on a dating website, and struggles to keep up the act.
Miller last appeared on the big screen in G.I. Joe: The Rise Of Cobra and Hippie Hippie Shake. Fraser's most recent outing was Furry Vengeance.
A Case of You is yet to be given a release date.