The actress is in talks for the Romeo and Juliet retelling, reports Variety.
The movie will be based on Rebecca Serle's debut novel When You Were Mine, which focuses on Romeo's spurned love in a modern-day setting, and is due to debut later this year.
Rose's (Collins) romance with handsome Rob is dashed apart upon the return of her cousin Juliet to town.
Formerly Rose's best friend, Juliet is now hostile, hateful and rumoured to have suicidal tendencies.
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Collins starred in last year's Abduction alongside Taylor Lautner and will feature in the forthcoming Mirror Mirror with Julia Roberts.
True Blood's Deborah Ann Woll and Dave Franco (Scrubs, Superbad) are reportedly also in negotiations for the other two starring roles.