Jolie's directorial debut is a love story set against the Bosnian War, which has earned wide critical praise as well as a Golden Globe nomination in the 'Foreign Language Film' category.
Speaking about In the Land of Blood and Honey, the Hollywood star said she hopes the movie will give audiences an appreciation for its international cast and crew.
"I hope people acknowledge the great talent of an extraordinary region of the world," Jolie said, reports Flicks and Bits.
"I hope people recognise the unity of a very brave cast from all over the region, who've come together across religious and ethnic lines, that's a symbol of hope and what we should be pushing for and encouraging in the region, in the world."
Jolie went on to say that she believes In the Land of Blood and Honey has even more resonance given the ongoing humanitarian crisis in Syria.
"I hope people think of these international issues, such as Syria now, all the other parts of the world where there's violence against women, where there is war," she explained. "When you see war, it's a movie, but I hope people relate to the characters.
"So when you see on TV tomorrow a bomb exploded in this place, maybe it will feel that more familiar because these people feel more familiar, people inside war feel more familiar."
Jolie previously revealed that she's written a screenplay about the Afghanistan War, but isn't sure she will produce the movie.
In the Land of Blood and Honey is now playing on limited release in the US.
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Watch a trailer for In the Land of Blood and Honey below: