The concluding film in Tom Six's trilogy, subtitled Final Sequence, has been confirmed by producer Ilona Six, reports Entertainment Weekly.
Tom Six has also cast himself in a supporting part in the latest instalment of the controversial horror series.
Laser and Harvey appeared as the mad scientist antagonists of the first and second movies respectively.
Ilona Six has promised that the final film will be "100% politically incorrect".
The Human Centipede 2 was initially banned in the UK. The ban was later lifted, but the film only took £942 at the UK box office on its debut weekend.
Principal photography on The Human Centipede 3 will take place in May and June, with a 2013 release planned.
> 'The Human Centipede 2' available uncut in UK and Australia?