Zoe Saldana, Billy Crudup, Marion Cotillard and James Caan also have confirmed roles in the project, according to The Hollywood Reporter.
Blood Ties will be directed by Cotillard's partner Guillaume Canet, and is an adaptation of French novel Les liens du sang.
The story follows a younger brother (Crudup), who is forced to ask his convict older brother (Owen) to return to the world of underground crime to protect their family.
Cotillard and Kunis will reportedly play the two leads' romantic interests.
The project is expected to begin filming in New York from April. Mark Wahlberg was once attached to the project in the lead role.
Clive Owen has been attached to star in the upcoming Oldboy remake from Spike Lee.
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