Robert De Niro is slated to reprise his role as bounty hunter Jack Walsh from the original 1988 action comedy, reports Deadline.
Charles Grodin has not been confirmed to return for the mismatched buddy movie, but had previously said that he would consider a return for the long-gestating sequel.
De Niro starred in Midnight Run as a bounty hunter charged with transporting an accountant who embezzled from the mob and gave the money to charity from New York to Los Angeles.
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Tim Dowling executed the first draft, with G.I. Joe and Four Brothers writers David Elliot and Paul Lovett now continuing work on the script.
Ratner is due to direct the Dwayne Johnson-starring Hercules: The Thracian Wars this year.
Watch the original Midnight Run trailer below: