Stone, who will star in the comic book movie later this summer as Gwen Stacy, is known for her comedic roles in Easy A, Zombieland and Crazy, Stupid, Love.
In an interview with Comic-Con Annual 2012, the actress revealed that she didn't feel she was right for the part of the scientist and love interest opposite Andrew Garfield's Peter Parker.
"I heard about Spider-Man and I didn't think it was something I would want to be a part of. I just thought that probably isn't right for me. Then I [auditioned with Andrew Garfield] and realised that this was a really interesting, fantastic relationship between two people and that I was being really closed-minded," she said.
The actress, who wore her naturally blonde hair for the part, went on to discuss how her character finally changed her mind about the film: "[I] started learning more about Gwen Stacy and her history and just fell in love with the character and with the fans, too. I started reading forums and getting involved more in the comic book universe and it just became something I really wanted to be a part of, just because of all those elements."
Bryce Dallas Howard, who played Gwen Stacy in Sam Raimi's Spider-Man 3 and also starred alongside Emma Stone in The Help, has said Stone is perfect for the role of Stacy.
The Amazing Spider-Man is scheduled for release on July 3 in the US and July 4 in the UK.
Watch a trailer for The Amazing Spider-Man below: