The drama from director Alex Kurtzman also stars Elizabeth Banks, Olivia Wilde and Michelle Pfeiffer.
Formerly known as Welcome to People, the film follows Sam (Pine), a struggling salesman, who is tasked with delivering $150,000 of his recently deceased father's wealth to the sister he has never met before (Banks).
People Like Us will open at US cinemas on June 29, 2012.
Chris Pine is currently filming Star Trek 2, and has signed up for Jack Ryan 5, with Kenneth Branagh tipped to direct.
Elizabeth Banks can currently be seen in The Hunger Games as Effie Trinket. She recently revealed that she struggled with wearing the character's nails.