The film, directed by newcomer John Stalberg, centers on a high school valedictorian who attempts to avoid the consequences of a failed mandatory drug test by attempting to get his entire school high on marijuana.
The trailer, released by ENTV, stars Colin Hanks, Michael Chiklis, Matt Bush and Cody Longo.
Adrien Brody stars as the paranoid drug dealer from whom the teens steal the necessary ingredients to execute their plan.
This marks a return to comedy for the Oscar-winning Brody, who last month starred in the indie drama Detachment.
He was recently in the running to star in Abraham Lincoln: Vampire Hunter, but lost out to Benjamin Walker.
High School is due for release on April 20 in the US.
Watch the trailer for High School below: