The Amazing Spider-Man director has said that he will offer a refreshed origin story for Peter Parker, partly focusing on the mystery of his parents.
"I wanted to give the audience something new," he told MTV News. "So that started off with getting underneath the parents' story, which will unfold over probably a few movies.
"We don't totally wrap up that story in this first movie. It's sort of an ongoing mystery."
Webb also said that some of the iconic set-pieces from the classic Spider-Man origin story from Amazing Fantasy #15 would be missing.
"[There are] obligations to the canon in terms of Uncle Ben and the spider-bite, but the conditions under which those things happen are very different," he said.
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"The character is evolving in a different way. It's about finding a balance between iconic elements of the 'Spider-Man' mythology - like how Uncle Ben's death transforms him emotionally - but it happens in a different way.
"He's bitten by a spider, but maybe it's not a radioactive spider. Or maybe it is! You'll have to see."
Michael Bay angered fans last month by revealing his alien origin for the new Teenage Mutant Ninja Turtle film.
Starring Andrew Garfield and Emma Stone, The Amazing Spider-Man will debut in cinemas worldwide on July 3.
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Watch a trailer for The Amazing Spider-Man below: