Rupert Everett and Felicity Jones also star in the upcoming comedy-drama from director Tanya Wexler.
The Victorian-era project centres around the invention of the vibrator, with two doctors working on an electrical device to treat irritable and angry women.
Watch the trailer below:
The new clip includes Sheridan Smith trying out Rupert Everett and Hugh Dancy's invention with promising results.
Jonathan Pryce and Ashley Jensen also appear in the film.
Hysteria opens in the US on May 18. A UK release date is yet to be confirmed.
> Maggie Gyllenhaal: 'I gave vibrators to Hysteria cast and crew'