The Rizzoli & Isles star told Entertainment Weekly that she would be the perfect choice to play Jennifer Walters because she related to the Hulk character in Joss Whedon's Avengers.
"I have to be her," she said. "You don't understand. I have to be her. It's the best quote ever when The Hulk turns around and goes, 'I'm always angry'. I was like, 'Oh my God!' I stood up in the theater and literally cheered. I did."
Harmon went on to say that she would have no reservations about donning the Marvel Comics character's revealing costume.
"I would rock that like there is no tomorrow. I would kill that outfit. I'd put these 36Cs on display," she added.
"And what about her libido? That's my favourite part. She-Hulk, bed! She-Hulk, screw! Can you imagine? Then she just picks him up and throws him around the room like the Hulk did with the bad guy."
Mark Ruffalo portrayed the Hulk in The Avengers. It is yet to be confirmed whether his female counterpart will be inducted into the Marvel movie universe in a future film.
Watch a trailer for The Avengers below: