Talking to Digital Spy at the world premiere of Prometheus, the scribe - who wrote Ridley Scott's return to the Alien universe as well as 2009's Star Trek and JJ Abrams's upcoming Star Trek 2 - compared the two visions of the future.
"Star Trek is a much more optimistic universe," Lindelof explained. "It's primary colours, it's blue and yellow and red.
"Ridley Scott's future, established in Alien and Blade Runner and carried through to Prometheus, is grey and gritty, and populated by tortured souls."
He went on to say that he enjoys the "breath of fresh air" allowed by switching between the two "very different visions of the future".
Benedict Cumberbatch recently dubbed his time filming Star Trek 2 as "solid extraordinary fun from beginning to end".
Chris Pine, who plays Captain Kirk in the rebooted Star Trek franchise, has described the upcoming sequel as "relentless".
Photo gallery - Prometheus world premiere: