The Avengers actor has agreed a deal to star in MGM's upcoming remake of the classic 1987 sci-fi film, says The Hollywood Reporter.
Joel Kinnaman will lead the cast of the new version as cop Alex Murphy who comes back from certain death and is turned into a robotic officer.
Jose Padilha will direct, while Gary Oldman will also star as RoboCop's creator.
Jackson will portray TV mogul Pat Novak, who is said to be a powerful figure in the city.
The Killing star Kinnaman recently said that RoboCop will be a "retelling".
Jackson will next appear in Quentin Tarantino's Django Unchained, to be released on December 25 in the US and January 18, 2013 in the UK.