Variety reports that indie animation distributor GKids has picked up the rights to the anime project, which debuted in Asia last year.
Spirited Away helmer Hayao Miyazaki wrote the screenplay for the film, with his son Goro taking up the director's chair.
From Up On Poppy Hill is set in Yokohama in 1963, and follows two school children's efforts to save a historic building from demolition. It was the highest-grossing Japanese movie of 2011, raking in $56 million (£35m).
Kathleen Kennedy and Frank Marshall are executive producing the English-language edition of the film, which marks GKids' first release of a first-run Studio Ghibli feature.
Disney previously held the distribution rights to the studio's catalogue in the West, but its contract concluded with the release of The Secret World of Arrietty earlier this year.
> 'Ni No Kuni' first English trailer released - watch
Watch a trailer for From Up On Poppy Hill below: