The 30 Rock star plays Dennis Dupree in the musical, based on the Broadway play of the same name. Tom Cruise, Catherine Zeta Jones and Mary J Blige also star.
In the film, Baldwin's character shares a kiss with Brand's character, which the actor has downplayed, telling The Hollywood Reporter: "It's not two leading men who you are used to getting it down with some gorgeous young girl. It's a little more chaste because I'm older [than Brand]."
However, Baldwin did suggest that the subtext in the scene has changed in light of the current social climate in the US.
He added: "We live in an age, and I'm being imprecise here, where half the country gets it, and the other half doesn't. I live where men and women who want to get married, who gives a s**t? No one gives it a thought.
"It's like seeing women in power. Or like seeing African-American CEOs. We're in a fully-realised age of equality in all things and it's not surprising or new. But there is that other half for whom that is surprising and new."
When asked about the scene earlier this month, Brand praised Baldwin's kissing, saying: "I'd do it again if there was a sequel - or even if there wasn't."
Rock of Ages comes out in cinemas on June 13 in the UK and June 15 in the US.
Watch a trailer for Rock of Ages below: