The TV stars both topped a Digital Spy poll asking Fifty Shades fans to pick their fantasy leads for the big screen version of EL James's best-selling erotica novel.
The poll, which registered more than 15,000 votes, saw Somerhalder run away with the casting race to play Christian Grey, a billionaire corporate CEO who indulges in BDSM.
Somerhalder took 35.8% of the vote, beating out the likes of Ryan Gosling (13.7%) and Alexander Skarsgård (10.5%).
1. Ian Somerhalder - 35.8%
2. Ryan Gosling - 13.7%
3. Alexander Skarsgård - 10.5%
4. Other - 8.5%
5. Matt Bomer - 7.4%
Clarke, known for playing Daenerys Targaryen on HBO's Game of Thrones, led the voting for the part of Anastasia Steele, the virginal college graduate who gives control of her life over to Grey.
1. Emilia Clarke - 15.5%
2. Lucy Hale - 12.4%
3. Kristen Stewart - 12.1%
4. Emma Watson - 11.5%
5. Other - 11.3%
American Psycho author Bret Easton Ellis has recently voiced his desire to pen the screen version of Fifty Shades of Grey, touting Somerhalder - who appeared in the Ellis-adapted film Rules of Attraction - as an ideal Christian Grey.
The Vampire Diaries actor claimed that he is not actively chasing the role.
He wrote on Twitter: "OK, this ChristianGrey thing has gotten out of control.Know this,Im not"desperate"to do anything except relax today (sic).
"Be positive people.Its what makes the world go round.Relax.Hating sucks.I probably wont even get to audition for the role-don't worry. Smile:)"
Fifty Shades of Grey, which originated as Twilight fan fiction, was reported to be the year's fastest-selling book in the UK earlier this week.
Publisher Random House confirmed that the novel had sold over four million physical and ebooks combined in the UK, Australia, New Zealand, India and South Africa.