The Notorious actor will appear opposite Paula Patton, who stars in the film as a flight attendant named Montana Moore, reports Variety.
Based on David Talbert's novel of the same name, the upcoming film follows Montana as she goes on a 30-day search for a potential husband.
Talbert adapted the screenplay and is also directing the movie.
Luke previously appeared in last year's Captain America: The First Avenger and 2009's Biggie Smalls biopic Notorious, as well as in TNT's medical drama HawthoRNe.
Patton is coming into the project following the success of Mission: Impossible - Ghost Protocol, the fourth instalment of Tom Cruise's spy agent franchise.
Watch Derek Luke discuss Notorious with Digital Spy below: