The comedy-drama follows a group of male strippers, and Soderbergh admitted that he had worried about attracting a male audience.
"There might have been a concern for men who have to see the film, and that the movie was so driven toward the female audience that there would be nothing in it for them to latch onto," the helmer told Collider.
"Of course, I knew that that wasn't what I wanted to do."
Soderbergh, who recently announced his upcoming sabbatical, went on to explain that while the profession of stripping might not be universal, the notion of being defined by a career is one that most men can relate to.
"In point of fact, some of the issues that the male characters are going through are issues that all men confront. Men tend to define themselves by what they do.
"If you're dealing with the characters, trying to figure that out, then there's something there for guys, too."
Magic Mike stars Channing Tatum and Matthew McConaughey as veteran strippers, and Alex Pettyfer as the new recruit who is taken under Tatum's wing.
Tatum has described the experience of wearing a thong as risky, saying: "A thong can completely betray you."
A Broadway adaptation of the film is reportedly in development.
Magic Mike is released on June 29 in the US, and July 11 in the UK. Watch the red band trailer below: