The action comedy follows former getaway driver Charlie (Shepard) who puts his witness protection identity at risk to help his fiancée (Bell) get to Los Angeles for her dream job.
The pair are pursued on the road by both Charlie's former gang and the FBI.
Bradley Cooper, Tom Arnold and Kristin Chenoweth are their co-stars in Hit and Run, which is written and co-directed (alongside David Palmer) by Shepard.
The first trailer was released last month.
Real-life couple Bell and Shepard recently stated that they will not marry until gay marriage is legalised across the US.
Hit and Run is released in the US on August 24. Watch the red band trailer below: