The project will blend live action sequences with CG Lego characters, and feature several superheroes from the DC Comics stable, Variety reports.
Chris Pratt has been recruited to portray a character named Emmet, while 21 Jump Street's Channing Tatum is being sought for the voice of Superman.
Cloudy With a Chance of Meatballs duo Phil Lord and Chris Miller are co-directing Lego: The Piece Of Resistance in collaboration with Robot Chicken helmer Chris McKay.
Warner Bros is producing the movie, which is based on a screenplay by Dan and Kevin Hageman.
Lego: The Piece Of Resistance arrives in US theatres in 2014.