The comedy drama follows a former college wrestler-turned-biology teacher (James) who decides to raise money for his failing school by taking up mixed martial arts.
Henry Winkler, Charice and Ally McBeal actor Greg Germann also star in the project.
It is directed The Wedding Singer's Frank Coraci, and was co-written by James, Rock Reuben and Allan Loeb.
The entire film was shot in just 20 days in Massachusetts, and was mostly filmed at Quincy High School.
Here Comes the Boom will be released in the US on October 12.