Sons of Anarchy star Charlie Hunnam is front and centre in the picture, which was revealed in the latest issue of Entertainment Weekly.
Actress Rinko Kikuchi (Babel, Norwegian Wood) appears alongside Hunnam in the image, while Idris Elba and Ron Perlman also star.
Pacific Rim centres on an alien attack on Earth, which sees humans piloting giant robots in an effort to fight off the enemy.
Elba has teased that the film's "big" monsters will not disappoint, while del Toro has promised to create "the finest f**king monsters ever committed to film".
Pacific Rim opens on July 13, 2013. Watch the trailer for last year's Don't Be Afraid of the Dark, written and produced by del Toro, below: