Wahlberg jokingly cautioned that he shouldn't be held responsible for potentially-offensive content in Ted, while speaking to The Daily Telegraph.
"The humour in the movie I guess you could say is similar to Family Guy, but Seth is probably pushing things a little bit more in this movie," the actor explained.
He continued: "I think it is going to offend more people than Family Guy does, but hey I didn't write it… I told them I want that as a disclaimer!"
Ted has already drawn a protest from an amyotrophic lateral sclerosis (ALS) support group over a line in the movie where Wahlberg wishes "Lou Gehrig's disease" on Joel McHale's character.
Traci Bisson of the ALS Therapy Alliance said in a statement: "We want to make it clear that ALS, or Lou Gehrig's disease, is not a laughing matter for people and families suffering from this life-threatening illness.
"The punchline in the movie Ted comes at the expense of people afflicted with ALS."
Wahlberg responded to the controversy this week by jokingly telling the ALS Therapy Alliance to "take it up" with MacFarlane.
Ted is now playing in the US and opens in the UK on August 1.
Watch a trailer for Ted below: