The duo will team up with Matt LeBlanc, Ali Larter, Chevy Chase and Kristin Johnson for the Luke Matheny-helmed project.
Lovesick stars LeBlanc as Charlie Darby, a man who becomes clinically insane every time he falls in love. The story sees the character attempt to overcome this problem when he meets the woman of his dreams.
CSI: Miami star Rodriguez joins the cast as Charlie's married best friend Jason, while Harris will portray an "aggressive date" of the protagonist's, Deadline reports.
In addition to his role in the cancelled US TV show, Rodriguez has appeared alongside Channing Tatum and Alex Pettyfer in Magic Mike. Harris has previously featured in The Hangover, The Soloist and Natural Selection.
Lovesick is yet to be given a official release date.