The comedian appeared in the first Hangover film as Black Doug, the man that Ken Jeong's Mr Chow returns to the three leads instead of their missing friend Doug, played by Justin Bartha.
According to Variety, Epps will take on the role again, though it is unknown how big a part he will play in the movie.
Original stars Bradley Cooper, Ed Helms and Zach Galifianakis have all signed on for a return to the Golden Globe-winning franchise.
It has also been announced that Ken Jeong's role as Mr Chow has been expanded for this next instalment.
Hangover 3 is scheduled for release on May 24, 2013 in the US and the UK.
Watch a trailer for Hangover 2 below: