Christopher Nolan's final Batman instalment pulls in £14.6 million to easily secure the number one spot ahead of Ice Age 4: Continental Drift and The Amazing Spider-Man.
The Dark Knight Rises's three-day total, from Friday through Sunday, is the highest of the year so far. It narrowly misses out on the biggest opening weekend of 2012 to The Avengers, whose £15.78 million total was aided by £2.55 million in previews.
The Batman trilogy closer's opening haul outpaces the £4.43 million earned by The Dark Knight in 2008 and the £4.43 million taken home by 2005's Batman Begins.
Seeking a Friend for the End of the World experiences the sharpest fall as it loses 83% in ticket sales on its second weekend in cinemas.
The UK box office top ten in full:
1. (-) The Dark Knight Rises - £14,362,443
2. (1) Ice Age 4: Continental Drift - £2,112,021
3. (2) The Amazing Spider-Man - £1,051,641
4. (3) Magic Mike - £885,330
5. (6) The Five-Year Engagement - £77,158
6. (5) Cocktail - £70,212
7. (4) Seeking a Friend for the End of the World - £59,788
8. (7) Men in Black 3 - £55,680
9. (8) Prometheus - £39,075
10. (9) Katy Perry: Part of Me - £38,327
Watch Digital Spy's video interview with Christopher Nolan below: