The pair of actors were working together on the film Total Recall of which Wiseman is the director.
Farrell and Beckinsale had to film a passionate love scene that was directed by Wiseman.
Speaking to Conan O'Brien, Farrell said: "She's actually the director's wife. She's married to the director. [It was] moderately uncomfortable...
"Kissing her was a little bit dodgy 'cause the director, her husband, wasn't kind enough to leave the room. Being a director, he had to watch the scene. It's a little bit creepy."
The film is a remake of Arnold Schwarzenegger's 1990 movie and will be released on August 29. Watch an exclusive clip below: