Actor Paul Fusco will return as the voice of the friendly, furry alien, according to The Hollywood Reporter.
The Smurfs producer Jordan Kerner is attached to the live action/CGI hybrid film along with Alf creators Tom Patchett and Fusco.
The '80s sitcom centred around the titular star - whose name stands for 'Alien Life Form' - who moves in with suburban family the Tanners after crash landing on Earth.
Fusco has previously expressed hopes for a movie return for the character.
The project is yet to acquire a writer or director.
The original Alf show ran from 1986 to 1990.
Watch the opening credits for the original Alf TV series below:
