The Bourne sequel, which sees Jeremy Renner take over the franchise from Matt Damon, pulls in an impressive $40 million to emerge as the number one movie ahead of Will Ferrell and Zach Galifianakis's political comedy The Campaign and The Dark Knight Rises.
Bourne Legacy's opening sits between the $27 million earned by Bourne Identity in 2002 and its sequel Bourne Supremacy's $52.5 million haul in 2004. The last instalment, The Bourne Ultimatum, grossed $69 million in August 2007.
Hope Springs, the romantic comedy starring Meryl Streep and Tommy Lee Jones, debuts at number four, while Diary of a Wimpy Kid: Dog Days completes the top five.
Last week's chart-topper Total Recall slides down four places to six after experiencing a 68% dip in second-week ticket sales.
The US box office top ten in full (weekend estimates):
1. (-) The Bourne Legacy - $40,265,000
2. (-) The Campaign - $27,440,000
3. (1) The Dark Knight Rises - $19,540,000
4. (-) Hope Springs - $15,600,000
5. (3) Diary of a Wimpy Kid: Dog Days - $8,200,000
6. (2) Total Recall - $8,100,000
7. (4) Ice Age 4: Continental Drift - $6,750,000
8. (6) Ted - $3,290,000
9. (7) Step Up Revolution - $2,850,000
10. (5) The Watch - $2,200,000
Watch The Bourne Legacy trailer below: